New therapy promotes vascular repair following stroke

New therapy promotes vascular repair following stroke

by University of Zurich

A promising new approach to promote the recovery of physiological functions aims to repair the system of blood vessels in the affected brain regions. The system supplies the injured tissue with oxygen and key nutrients. In people who have suffered a stroke, this repair process is inhibited by a number of mechanisms. A few years ago, the research group of UZH Professor Martin Schwab used a mouse model to, among other things, show that the signaling molecule Nogo-A not only reduces the growth of nerve fibers, but also regulates blood vessel sprouting in the brain and could thus also inhibit their repair.

Motor function improvement thanks to vascular growth

In a new study with mice, the researchers genetically deactivated the Nogo-A molecule or one of its corresponding receptors, S1PR2. The blood vessels in these mice showed improved regenerative capacity, and they recovered affected motor skills better than those of the mice in the control group. These findings were reproduced in a therapeutic approach using anti-Nogo-A antibodies in mice following a stroke, which too led to the re-formation of a robust and functional vascular network around the affected brain regions. "The nervous system of the treated mice showed better recovery and their motor functions were less affected, which we ascribe to vascular regeneration," says first author and UZH neuroscientist Ruslan Rust.

Nogo-A antibodies already in clinical tests for spinal cord injuries