The OPEN Foundation and the Essentia Foundation together hosted a panel debate on metaphysics at the latest Interdisciplinary Conference on Psychedelic Research (ICPR26), Europe's leading scientific conference dedicated to psychedelic science, therapy, ethics, and policy. During this discussion, Anil Seth, Bernardo Kastrup and Christof Koch discuss the latest insights from psychedelic research, as well as their different viewpoints on the epistemic value of psychedelic experiences and what metap