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Neural correlates of consciousness at near-electrocerebral silence in an asphyxial ca
Neural correlates of consciousness at near-electrocerebral silence in an asphyxial cardiac arrest model


Recent electrophysiological studies have suggested surges in electrical correlates of
consciousness (i.e., elevated gamma power and connectivity) following cardiac arrest (CA). The
present study examines electrocorticogram (ECoG) activity and coherence of the dying brain
during asphyxial CA. Male Wistar rats (n = 16) were induced with isoflurane anesthesia, which
was washed out prior to asphyxial CA. Mean phase coherence and ECoG power were compared
during different stages of the asphyxial period to assess potential neural correlates of
consciousness. Following asphyxia, the ECoG progressed through 4 distinct stages (AS1-4),
including a transient period of near-electrocerebral silence lasting several seconds (AS3).
Electrocerebral silence (AS4) occurred within 1 minute of the start of asphyxia, and pulseless
electrical activity followed the start of AS4 by 1-2 minutes. AS3 was linked to a significant
increase in frontal coherence between the left and right motor cortices (p < 0.05), with no
corresponding increase in ECoG power. AS3 was also associated with a significant posterior
shift of ECoG power, favoring the visual cortices (p < 0.05). While the ECoG during AS3 will
appear visually flat or silent when viewed with standard clinical settings, our study suggests that
this period of transient near-electrocerebral silence contains distinctive neural activity.
Specifically, the burst in frontal coherence and posterior shift of ECoG power that we find during
this period immediately preceding CA may be a neural correlate of conscious processing.

Haven't read it properly yet, but it seems like they got similar results to Borjigin's previous study.

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